What question did this study set out to answer?

This research aims to evaluate the necessity of antiviral treatment for chronic hepatitis B patients with normal ALT levels across different phases.

Histopathological Evaluation and Treatment Necessity in Patients with Immune-Tolerant, Inactive, and Gray-Zone Chronic Hepatitis B

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Retrospective evaluation of antiviral therapy need in chronic hepatitis B phases, suggesting implications for management.

This research aims to evaluate the necessity of antiviral treatment for chronic hepatitis B patients with normal ALT levels across different phases.
Retrospective cross-sectional analysis
Included immune-tolerant HBeAg-positive, inactive HBeAg-negative, and gray-zone patients
Assessed liver fibrosis stage and histological activity index (HAI)
Identified distinct liver conditions among immune-tolerant, inactive, and gray-zone patients
Determined the need for antiviral therapy based on liver fibrosis and HAI scores

Mehmet Kasim Aydin (2026) studied this question.

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