Demonstrates enhanced photoreceptor survival in hereditary retinal degenerations using minocycline and BM-MNCs, implying potential for combined therapies.
Minocycline and BM-MNCs provide complementary neuroprotective effects in the RCS rat model. While minocycline reduces microglial activation, BM-MNCs modulate macroglial response. Their combination enhances photoreceptor survival and synaptic preservation more effectively than either treatment alone. These findings support the therapeutic potential of combining pharmacological and cell-based interventions in hereditary retinal degenerations.
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Videla‐Ristol et al. (2026) studied this question.
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