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March 13, 2026Clinical Cancer Research2 citationsOpen Access

Decoding B Cell Signatures of Complete Pathological Response to Perioperative Chemoimmunotherapy in Non-Small Cell Lung Cancer.

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BSBelen Sierra-RoderoÁGÁngeles Gil-GonzálezMMMarta Molina-Alejandre

Key Points

  • The research aims to investigate the relationship between B cell responses and complete pathological response in lung cancer patients receiving perioperative therapy.
  • Analyzed pre-existing B cell responses in patients with complete pathological response tumors.
  • Monitored B cell maturation during neoadjuvant chemoimmunotherapy.
  • Evaluated B cell receptor (BCR) metrics as potential predictive biomarkers.
  • Patients with complete pathological response had a more mature B cell response.
  • B cell-related features significantly correlated with complete pathological response.
  • BCR metrics emerged as promising predictive biomarkers in non-small cell lung cancer.

Abstract

Patients with CPR tumors exhibit a pre-existing and more mature B cell response that develops further during neoadjuvant ChIO. Our findings link B cell-related features to CPR and highlight BCR metrics as promising predictive biomarkers in NSCLC.

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Cite This Study

Sierra-Rodero et al. (2026) studied this question.

synapsesocial.com/papers/69b3abe702a1e69014ccd20bhttps://doi.org/10.1158/1078-0432.ccr-25-3315
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