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The research aims to explore lesions and viral replication across multiple organs during various infection stages of mouse kidney parvovirus.

March 13, 2026

Ultrastructural pathology and temporal patterns of viral replication and lesion development following mouse kidney parvovirus infection in B6, CD1, and NSG mice.

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Investigates viral replication and kidney lesions in different mouse strains after parvovirus infection, indicating strain-specific responses.

The research aims to explore lesions and viral replication across multiple organs during various infection stages of mouse kidney parvovirus.
Experimental oronasal inoculation of mice with mouse kidney parvovirus (MKPV)
Evaluation at 15 time points from 1.5 to 112 days post-inoculation (DPI)
Histological analysis and in situ hybridization for MKPV RNA
Immunohistochemistry for immune cell markers and renal injury assessment
Initial viral replication was detected in gastrointestinal mucosa at 3 DPI without lesions
Renal tubule replication first observed at 28 DPI in B6 and 14 DPI in CD1 mice
Severe nephritis was noted later, with variations among strains
NSG mice showed the highest viral replication and associated tubular damage at 42 DPI

Miranda et al. (2026) studied this question.

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Investigates viral replication and kidney lesions in different mouse strains after parvovirus infection, indicating strain-specific responses.