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March 13, 2026The Laryngoscope

The Mental Health Impact of Retrograde Cricopharyngeus Dysfunction ( RCPD ) and Its Treatment

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Authors

ASAlexander SimkoATAndrew Tritter

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Overview

Evaluates anxiety and depression in RCPD patients, highlighting botulinum toxin's effectiveness as treatment.

Key Points

  • This study assesses the prevalence of anxiety and depression in patients with retrograde cricopharyngeus dysfunction and the efficacy of botulinum toxin treatment.
  • Conducted a questionnaire-based study on RCPD patients receiving cricopharyngeal botulinum toxin injections.
  • Participants completed anxiety and depression assessments (GAD-7, PHQ-9, ASQ) before, 6 weeks, and 6 months after treatment.
  • Analyzed changes in scores using ANOVA and established clinically significant improvements with minimal clinically important differences.
  • Seventy-seven RCPD patients completed the initial questionnaire, with 69 receiving treatment.
  • GAD-7 scores showed a significant decrease from 8.16 to 4.4 (p < 0.001) post-treatment.
  • PHQ-9 scores reduced from 7.87 to 4.20 (p = 0.002), indicating decreased depression levels.
  • 64% of patients reported significant improvement in anxiety and 60% in depression after treatment.

Cite This Study

Simko et al. (2026) studied this question.

synapsesocial.com/papers/69b3ac1d02a1e69014ccd820https://doi.org/10.1002/lary.70483
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