Synthesis of acyl hydrazide derivatives of α-naphthalene acetic acid as COX-2 inhibitors: in vitro evaluation, molecular docking and DFT studies

Key Points

• This research aims to synthesize acyl hydrazide derivatives of α-naphthalene acetic acid and evaluate their COX-2 inhibitory effects.
• Synthesis of acyl hydrazide derivatives
• Evaluation of inhibitory activity in vitro
• Molecular docking studies
• Density Functional Theory (DFT) calculations
• Compound 13 shows significant COX-2 inhibition
• Molecular docking supports strong binding affinity
• DFT calculations confirm stability of the synthesized compounds.