Influence of transporter polymorphisms on digoxin serum concentrations: a systematic review and meta-analysis.

Key Points

• This research aims to evaluate how ABCB1 polymorphisms affect serum concentrations of digoxin.
• Conducted a systematic review of existing studies on ABCB1 polymorphisms and digoxin levels.
• Performed a meta-analysis to calculate the effect size of these polymorphisms on serum concentrations.
• Reviewed studies that reported data on digoxin serum levels in relation to ABCB1 C3435T variants.
• The ABCB1 C3435T polymorphism significantly influences digoxin serum concentrations.
• Increased genetic variation corresponded with notable changes in digoxin levels, suggesting variability in drug effectiveness.
• The findings support the need for genotype-guided therapy in administering digoxin.