Experimental and computational studies demonstrate improved yield and selectivity in cross-coupling reactions using a dual-ligand system, suggesting new catalytic methods.
Key Points
This research aims to establish how a dual-ligand system improves decarbonylative Suzuki–Miyaura cross-couplings.
Utilized a pair of phosphine ligands in palladium-catalyzed reactions.
Performed both experimental and computational studies.
Investigated the ligand-relay mechanism for enhanced performance.
Achieved improved yields and selectivity in reactions compared to using single ligands.
Validated the efficacy of pooling-deconvolution screening method for identifying catalytic mechanisms.
Demonstrated cooperativity between ligands enhances reaction efficiency.