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March 13, 2026Environmental Science Nano2 citationsOpen Access

Polystyrene Nanoplastic Exposure Promotes Amyloid Misfolding and Metabolic Impairment at Sub-Lethal Doses. A Subcellular Infrared Imaging Study

ISIran Augusto Neves da SilvaAPAgnes PaulusVSV. R. Skoryk

Key Points

  • This research aims to explore how exposure to polystyrene nanoplastics influences amyloid misfolding and metabolic processes.
  • Utilized subcellular infrared imaging techniques.
  • Assessed amyloid misfolding at various concentrations of polystyrene nanoplastics.
  • Evaluated metabolic impairment in cells exposed to nanoplastic particles.
  • Exposure to polystyrene nanoplastics induced significant amyloid misfolding.
  • Metabolic impairment was observed even at sub-lethal doses.
  • Findings suggest a direct link between nanoplastic exposure and neurotoxic effects.

Abstract

Microplastics and nanoplastics (MNPs) are ubiquitous environmental pollutants with increasing implications for human health. While their presence in human tissues is established, the molecular mechanisms driving their potential neurotoxicity remain...

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Cite This Study

Silva et al. (2026) studied this question.

synapsesocial.com/papers/69b3ac7002a1e69014cce255https://doi.org/10.1039/d5en01181g
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Also Consider

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  4. 4Polystyrene Nanoplastics in Human Gastrointestinal Models—Cellular and Molecular Mechanisms of Toxicity2025 · 18 citations
  5. 5Polystyrene nanoplastics induce mitochondrial dysfunction and stress responses in human PBMCs2026