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RCT shows omega-3 fatty acids do not improve outcomes in youths with major depressive disorder, indicating lack of efficacy.
Researchers have found that omega‐3 fatty acids such as eicos‐apentaenoic acid (EPA) and docosahexaenoic acid (DHA), as an adjunct to antidepressants, do not outperform placebo in youths with major depressive disorder.
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Alison Knopf (2026) studied this question.
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