Glycosylation constitutes a master regulatory code that coordinates trophoblast development and function across gestation. The spatiotemporal specificity of glycosylation patterns ensures proper placentation and maternal-fetal interface maintenance, while its dysregulation contributes significantly to pregnancy pathologies. Understanding this dynamic system opens new avenues for biomarker discovery and therapeutic interventions, with emerging glycomic technologies poised to translate these findings into clinical applications for managing complicated pregnancies.
Wang et al. (2026) studied this question.