SERS-Assisted Multivariate Data Analysis of Spectinomycin-Cu(II) Complex Released in Blood Serum from Stimuli-Responsive Drug Carrier: In-Vitro Kinetics Modeling and Pharmacodynamic Analysis

Key Points

• This research focuses on assessing the release kinetics and pharmacodynamic behavior of spectinomycin from a stimuli-responsive drug carrier.
• Utilized surface-enhanced Raman spectroscopy (SERS) for data collection.
• Applied multivariate data analysis to interpret the release profiles.
• Conducted in-vitro experiments to model kinetics and pharmacodynamics.
• Identified significant patterns in the release kinetics of spectinomycin.
• Demonstrated effective control of drug release influenced by external stimuli.
• Provided detailed pharmacodynamic insights into the drug's behavior in serum.