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March 13, 2026European Journal of Orthodontics0 citations

Dynamics of salivary stress-related biomarkers in children with malocclusion and risk for sleep problems and sleep-disordered breathing: a cross-sectional study

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SMShugo ManaseTsurumi UniversityAIAiko ItoTsurumi UniversityFKFumitaka KobayashiTsurumi University

Key Points

  • This research aims to investigate the relationship between salivary stress biomarkers and sleep-related issues in children with malocclusion.
  • Conducted a cross-sectional study design
  • Compared salivary oxytocin levels in children at risk for sleep problems
  • Evaluated craniofacial features related to sleep-disordered breathing
  • Children at higher risk for sleep problems had reduced levels of salivary oxytocin
  • Group at risk for sleep-disordered breathing showed differences in craniofacial structure without biomarker changes
  • Vertical skeletal divergence was noted in children with greater sleep problem risks

Abstract

Children at elevated risk for general sleep problems showed reduced salivary oxytocin and greater vertical skeletal divergence, whereas those at elevated SDB risk exhibited anteroposterior craniofacial differences without biomarker alterations.

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Cite This Study

Manase et al. (2026) studied this question.

synapsesocial.com/papers/69b3acb202a1e69014cce9b4https://doi.org/10.1093/ejo/cjag004
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