Network pharmacology and molecular docking reveal Polygonum multiflorum's benefits for premature ovarian insufficiency, suggesting a novel treatment approach.
Polygonum multiflorum Thunb. may alleviate POI by activating the PI3K/AKT pathway, restoring hormonal balance, reducing follicular atresia, and preserving ovarian reserve. These findings underscore the potential of PM as a natural therapeutic resource for POI management.
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Li et al. (2026) studied this question.
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