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March 13, 20260 citationsOpen Access

Formulation Of Buccal Adhesive Tablet Using Natural Polymers

Formulation and Evaluation of Buccal Adhesive Tablet of Promethazine Hydrochloride Using Natural Polymers

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Authors

APAaditya Dinkar Suryawanshi*, Kiran Satnami, Deepak Basedia, B. K. Dubey, Sunil K. Shah, Mukesh K. Patel

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Overview

Formulates buccal adhesive tablets of promethazine hydrochloride, indicating improved drug release and bioavailability.

Key Points

  • The study aims to formulate and evaluate buccal adhesive tablets to enhance drug delivery and bioavailability of promethazine hydrochloride.
  • Formulated tablets using natural polymers like HPMC, Carbopol, and sodium alginate.
  • Conducted preformulation studies to ensure drug purity and suitability.
  • Prepared tablets via direct compression and assessed pre- and post-compression parameters.
  • Evaluated swelling index and in vitro drug release characteristics.
  • Formulation F5 showed optimal swelling characteristics and sustained drug release (98.15% over 12 hours).
  • The drug release followed a non-Fickian release mechanism with first-order kinetics.
  • All formulations exhibited satisfactory physicochemical properties and mucoadhesive behavior.

Cite This Study

Aaditya Dinkar Suryawanshi*, Kiran Satnami, Deepak Basedia, B. K. Dubey, Sunil K. Shah, Mukesh K. Patel (2026) studied this question.

synapsesocial.com/papers/69b3acc502a1e69014ccec53https://doi.org/10.5281/zenodo.18949167
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