Continuous administration of alpha radionuclide therapy: a proof-of-concept based on black hole like-dynamics

Key Points

• The study aims to explore if adaptive control strategies can enhance alpha radionuclide therapy (alpha-RPT) by adjusting treatment based on tumor state.
• Investigated dynamic adjustments in radiation therapy administration based on tumor conditions.
• Utilized biomarker data and theranostic imaging to inform treatment decisions.
• Developed a proof-of-concept model for testing adaptive control in alpha-RPT.
• Adaptive control strategies showed potential to address limitations of current alpha-RPT protocols.
• Dynamic adjustments in treatment led to improved responsiveness based on tumor state.
• Foundational insights were gained into how tumor dynamics can guide therapy administration.