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March 13, 2026Frontiers in ImmunologyOpen Access

Clinical characteristics and decreased CD4+CD25+Foxp3+ regulatory T cells and IL-35 in pediatric immune thrombocytopenia in a single center

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Authors

YYYan YangHuazhong University of Science and TechnologyDLDan LuThe Affiliated Yongchuan Hospital of Chongqing Medical UniversityBWBei WuHuazhong University of Science and Technology

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Implication

Observational analysis identifies distinct clinical and immunological features in pediatric ITP, suggesting IL-35 as a therapeutic target.

Key Points

  • To analyze clinical characteristics and immunological profiles in newly diagnosed pediatric patients with ITP.
  • Enrolled 240 newly diagnosed pediatric ITP patients
  • Analyzed demographic details, clinical manifestations, and treatment responses
  • Lymphocyte subsets assessed via flow cytometry and cytokines measured using ELISA
  • Most patients were under 1 year old, with a male predominance in this group
  • High overall response rate of 99.17% observed at 1-month follow-up
  • Significantly decreased regulatory T cells and reduced IL-35 levels noted
  • Long-term chronic ITP rate of only 8.3%, lower than in adults

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69b3acd302a1e69014ccede9https://doi.org/10.3389/fimmu.2026.1782560
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Also Consider

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  1. 1Establishing Reference Values for Peripheral Blood Lymphocyte Subsets of Healthy Children in China Using a Single Platform2022 · 20 citations
  2. 2Updated international consensus report on the investigation and management of primary immune thrombocytopenia2019 · 1,165 citations
  3. 3An update on the pathophysiology of immune thrombocytopenia2020 · 150 citations