Tetrahydropalmatine alleviates cancer induced bone pain by inhibiting TRPV1-SP-mediated macrophage recruitment and promoting M2 polarization.

Key Points

• This research aims to explore how tetrahydropalmatine alleviates cancer induced bone pain through immune modulation.
• Utilized a dual mechanism approach focusing on macrophage recruitment
• Investigated the TRPV1-SP pathway's role
• Analyzed macrophage polarization states during treatment
• THP significantly reduced the early stages of cancer induced bone pain
• Effective modulation of macrophage polarization towards M2 phenotype
• Inhibition of TRPV1-SP pathway led to less macrophage recruitment