Demonstrates THP alleviates cancer induced bone pain by regulating macrophage recruitment and polarization, suggesting its potential for treatment.
In conclusion, THP mitigates CIBP through a dual mechanism: regulating macrophage recruitment via the TRPV1-SP pathway in the early stage to inhibit CIBP initiation and directly modulating the migrated macrophage polarization. This study provides novel insights into THP's analgesic mechanisms and supports its potential as a preclinical candidate for CIBP treatment.
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Zhang et al. (2026) studied this question.
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