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March 13, 2026Reproductive SciencesOpen Access

Early Placental Angioactive Response to Maternal SARS-CoV-2 Infection: an Immunohistochemical Study

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Authors

AQAntonio Carlos de QuadrosTFThamirys Cosmo Grillo FajardoMSMaurício Feliciano da Silva

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Overview

Immunohistochemical study reveals placental changes due to maternal SARS-CoV-2 infection, suggesting adaptation mechanisms.

Key Points

  • To investigate the impact of maternal SARS-CoV-2 infection on placental morphology and expression of angioactive and inflammatory factors.
  • Analyzed placental samples from 23 pregnant women tested for COVID-19
  • Classified subjects into three groups: Viremia Group (VG), Serology Group (SG), and Control Group (CG)
  • Conducted PCR and immunohistochemistry for angioactive factors
  • Examined placental morphology through H&E staining and immunostaining
  • SG exhibited greater morphological changes compared to CG, including increased syncytial knots and fibrin deposits
  • VG showed more frequent vascular dilation and chorioangiosis
  • Higher expression of VEGF, COX2, and eNOS in VG, compared to CG
  • SG had decreased PlGF levels while COX2 and iNOS levels were elevated

Cite This Study

Quadros et al. (2026) studied this question.

synapsesocial.com/papers/69b3ad0502a1e69014ccf3cahttps://doi.org/10.1007/s43032-026-02079-7
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  4. 4Alterations in the Placenta Following Vaccination and Infection with SARS-CoV-2 During Pregnancy2026
  5. 5SARS-CoV-2 Infection during Delivery Causes Histopathological Changes in the Placenta2024 · 6 citations