Spatial single-cell proteotyping reveals immunotherapy-resistant features within the complex tumor microenvironment of metastatic NSCLC | Synapse
March 13, 2026Open Access
Spatial single-cell proteotyping reveals immunotherapy-resistant features within the complex tumor microenvironment of metastatic NSCLC
Key Points
To investigate the specific features that confer immunotherapy resistance in metastatic non-small cell lung cancer (NSCLC) using spatial single-cell proteotyping.
Conducted spatial single-cell proteotyping on tumor samples from metastatic NSCLC cases.
Analyzed cellular interactions within the tumor microenvironment.
Identified specific proteins associated with resistance to immunotherapy.
Found distinct immunotherapy-resistant features in the tumor microenvironment.
Identified several biomarkers linked to resistance traits.
Revealed complex cellular signaling pathways contributing to tumor adaptation.
Abstract
Osaka Cancer Society, KANAE Foundation for the Promotion of Medical Science, SGH Foundation, and YOKOYAMA Foundation for Clinical Pharmacology.