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January 1, 2026RSC AdvancesOpen Access

Pyrazole/pyrimidine derivatives endowed with azobenzenes as dual EGFR T790M and VEGFR-2 inhibitors: anticancer, docking, synthesis, design and ADMET assessments

Kurls E. Anwer Mohamed A. Abdelgawad Felemban Athary Abdulhaleem M Nour E. A. Abd El-Sattar Ahmed El-morsy Tamer Nasr Mohammed Elmowafy Khaled El-Adl Naglaa M. Ahmed

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Key Points

This research aims to develop new derivatives targeting EGFR T790M and VEGFR-2 for cancer treatment.
Synthesis of pyrazole/pyrimidine derivatives using microwave and traditional methods.
Assessment of anticancer properties through docking studies.
Conducting ADMET (absorption, distribution, metabolism, excretion, toxicity) evaluations.
New derivatives exhibited significant inhibition of EGFR T790M and VEGFR-2.
Compounds showed promising anticancer activities in preliminary tests.
ADMET assessments indicated favorable profiles for further development.

Implication

New pyrazole/pyrimidine derivatives show anticancer activity in vitro, suggesting potential as targeted therapies.

Abstract

New pyrazole/pyrimidine derivatives endowed with azobenzenes were synthesized using microwave and traditional methods.

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Cite This Study

Anwer et al. (2026) studied this question.

synapsesocial.com/papers/69b3ad6c02a1e69014ccf702 https://doi.org/10.1039/d5ra08997b

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