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March 13, 2026RSC Advances7 citationsOpen Access

Pyrazole/pyrimidine derivatives endowed with azobenzenes as dual EGFR T790M and VEGFR-2 inhibitors: anticancer, docking, synthesis, design and ADMET assessments

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KAKurls E. AnwerMAMohamed A. AbdelgawadJouf UniversityFMFelemban Athary Abdulhaleem MUmm al-Qura University

Key Points

  • This research aims to develop new derivatives targeting EGFR T790M and VEGFR-2 for cancer treatment.
  • Synthesis of pyrazole/pyrimidine derivatives using microwave and traditional methods.
  • Assessment of anticancer properties through docking studies.
  • Conducting ADMET (absorption, distribution, metabolism, excretion, toxicity) evaluations.
  • New derivatives exhibited significant inhibition of EGFR T790M and VEGFR-2.
  • Compounds showed promising anticancer activities in preliminary tests.
  • ADMET assessments indicated favorable profiles for further development.

Abstract

New pyrazole/pyrimidine derivatives endowed with azobenzenes were synthesized using microwave and traditional methods.

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Cite This Study

Anwer et al. (2026) studied this question.

synapsesocial.com/papers/69b3ad6c02a1e69014ccf702https://doi.org/10.1039/d5ra08997b
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