Efficacy and Safety of Intra‐Articular Therapies for Temporomandibular Disorders: A Systematic Review and Meta‐Analysis

This is a Systematic Review study.

March 12, 2026Oral DiseasesOpen Access

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Key Points

This review aims to evaluate the efficacy and safety of intra-articular therapies for temporomandibular disorders.
Conducted a systematic review and meta-analysis of available studies on intra-articular therapies.
Analyzed outcomes related to pain reduction and maximum mouth opening (MMO).
Evaluated the effectiveness of therapeutic agents like Tenoxicam and opioids.
Tenoxicam showed promising results for pain reduction and improvement in MMO.
Opioids also demonstrated efficacy, but evidence remains limited.
Further high-quality studies are needed to establish clinical applicability.

Systematic review shows tenoxicam and opioids may reduce pain in temporomandibular disorders, suggesting further studies are needed.

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Santos et al. (2026) studied this question.

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