Delivery of AgNP led to more pronounced local retention in the subcutaneous versus intraperitoneal location with limited uptake and toxic effects in rats

Key Points

• The aim is to evaluate the retention and systemic effects of AgNP delivered in different locations in rats.
• Evaluated AgNP delivery in subcutaneous and intraperitoneal locations in rats.
• Assessed local retention and uptake as well as toxic effects after delivery.
• AgNP showed more local retention in the subcutaneous location compared to intraperitoneal.
• Limited uptake and toxic effects were observed with AgNP delivery.