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Retrospective cohort study shows reduced risk of severe COVID-19 outcomes in older adults, suggesting inherent selection biases.
The first booster vaccination was associated with significantly reduced the risk of COVID-19-related severe outcomes in older inpatients aged ≥80 years during the Omicron-dominant period. Considering the potential selection bias and unmeasured confounders, these estimates may reflect both the VE and the better baseline health status of the vaccinated older individuals.
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Zhao et al. (2026) studied this question.
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