What type of study is this?

This is a Cross-Sectional Study study.

What question did this study set out to answer?

This study examines the impact of race and ethnicity on KRAS variant frequency and colorectal cancer-specific survival.

March 14, 2026JAMA Network Open3 citationsOpen Access

KRAS Variant Frequency and Colorectal Cancer–Specific Survival by Race and Ethnicity

GRGladys Magaly RodriguezNorthwestern University MAMayada AljehaniKing Saud bin Abdulaziz University for Health Sciences DDDylan DePuyUniversity of Southern California

Key Points

This study examines the impact of race and ethnicity on KRAS variant frequency and colorectal cancer-specific survival.
Cross-sectional study design
Analysis of colorectal cancer patients by race and ethnicity
Comparison of KRAS variant prevalence and survival outcomes among groups.
Hispanic and non-Hispanic Black patients showed higher KRAS variant prevalence than non-Hispanic White patients.
Non-Hispanic Black patients with KRAS variants had worse survival compared to non-Hispanic White patients.
Hispanic patients with wild-type KRAS had worse survival compared to non-Hispanic White patients.

Abstract

In this cross-sectional study of patients with colorectal cancer, Hispanic patients and non-Hispanic Black patients had higher KRAS variant prevalence than non-Hispanic White patients. Among patients with a KRAS variant, non-Hispanic Black patients had worse cause-specific survival than non-Hispanic White patients. Among patients with wild-type KRAS, Hispanic patients had worse survival compared with non-Hispanic White patients. These findings highlight the need for further research on racial and ethnic differences in KRAS-related outcomes.

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