This research demonstrates glycoconjugation of oligonucleotides using click chemistry, targeting glucose transporters and specific receptors.
The synthesis of novel carbohydrate-oligonucleotide conjugates is described. These bioconjugates, which feature glycosyl-nucleoside moieties linked to a thymine base via a 1,2,3-triazole linker, were prepared using a 'click' chemistry route. This synthetic approach enables the generation of oligonucleotide conjugates designed to engage specific sugar receptors, including glucose transporters as well as GalNAc and maltoheptaose-binding receptors.
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Majumdar et al. (2026) studied this question.
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