PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 14, 2026Diabetes Obesity and Metabolism6 citationsOpen Access

Obesity Treatments and Weight Changes in Clinical Practice After Discontinuation of Semaglutide or Tirzepatide

View Full Paper
HGHamlet GasoyanRSRebecca SchulteCBChristopher Boyer

Key Points

  • To examine the weight changes in patients after discontinuing semaglutide or tirzepatide and the frequency of reinitiation or alternative treatments.
  • Large sample of patients analyzed post-discontinuation of semaglutide or tirzepatide
  • Observed weight changes one year after discontinuation
  • Investigated rates of reinitiation of the medication or receipt of alternative obesity treatments.
  • Average weight change one year post-discontinuation was relatively small
  • Significant individual-level variability in weight changes was observed
  • Common reinitiation of original medication or alternative treatments post-discontinuation.

Abstract

In this large sample of patients who discontinued semaglutide or tirzepatide, reinitiation of the original medication or receipt of alternative obesity treatment was common. The average weight change 1-year post-discontinuation was relatively small; however, there was considerable individual-level variability.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Gasoyan et al. (2026) studied this question.

synapsesocial.com/papers/69b4adc718185d8a39801b6ehttps://doi.org/10.1111/dom.70660
Ask AI
Helpful
Bookmark
Share
View Full Paper