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This research shows high intrahepatic cccDNA in resolved HBV infection, suggesting improved serum markers may enhance HBV prophylaxis.
Even among patients with resolved HBV infection, there are cases possessing intrahepatic cccDNA levels as high as or even higher than those in HBsAg-positive patients. To resolve this critical pitfall in immunosuppressed patients, the development of serum markers that precisely reflect intrahepatic cccDNA levels will be essential for improving HBV prophylaxis strategies.
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Bae et al. (2026) studied this question.
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