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March 14, 2026Applied Food Research1 citationsOpen Access

Ultrasonic Extraction of Saponin from Wild Bitter Melon Using Response Surface Methodology

Ultrasonic-assisted extraction of total saponin from Wild Bitter Melon (Momordica charantia Linn. Var. Abbreviata Ser.) with response surface methodology and kinetic analysis

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Authors

SLSon Hong LuuCDCuong Manh DuongVPVinh Thi Pham

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Overview

Demonstrates optimal conditions for total saponin extraction in wild bitter melon, suggesting improvements for industrial applications.

Key Points

  • To determine optimal extraction conditions for total saponin content from wild bitter melon using kinetic analysis and response surface methodology.
  • Utilized ultrasonic-assisted extraction for saponin extraction.
  • Applied response surface methodology (RSM) to optimize extraction conditions.
  • Conducted single-factor analysis for the solvent/sample ratio, ultrasonication time, and temperature.
  • Implemented the Box–Behnken design to evaluate extraction performance.
  • Achieved maximum total saponin content of 82.92 mg/g under optimal conditions.
  • Optimal extraction parameters identified were a solvent/sample ratio of 26.89 mL/g, temperature of 66.22 °C, and ultrasonication time of 21.33 min.
  • Kinetic analysis using the Luong model effectively captured extraction dynamics.

Cite This Study

Luu et al. (2026) studied this question.

synapsesocial.com/papers/69b4b9db18185d8a39801ee3https://doi.org/10.1016/j.afres.2026.101872
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