Nanoparticles are widely used in anticancer drugs, antimicrobial agent, degradation of harmful organic dyes, and waste water treatment etc. In the present investigation on iron oxide nanoparticles (IONPs) are biosynthesized by using solanum trilobatum extract as reducing and stabilizing agent. This eco-friendly method offers a sustainable alternative to conventional chemical synthesis along with low toxicity. The iron oxide nanoparticles were subjected to anticancer activity. The chemical structure, morphological, and optical properties of synthesized Solanum trilobatum iron oxide nanoparticles were characterized by using UV-VIS spectroscopy, FTIR, XRD, DLS with zeta potential, SEM, TEM and EDX. The results confirmed the successful formation of iron oxide nanoparticles with controlled size distribution and colloidal stability. Biological evaluation through MTT-assay revealed that the iron oxide nanoparticles exhibited significant, dose-dependent cytotoxicity against panc1 cells while displaying minimum toxicity towards normal McCoy fibroblast cells. These findings suggest that the Solanum trilobatum synthesized Iron oxide nanoparticles are safe and show potential for further investigation for pre-clinical studies for targeted cancer therapy.
Koyyalamudi et al. (Tue,) studied this question.