Observational study shows neoadjuvant chemoimmunotherapy improves pathologic and radiographic response in HNSCC, suggesting further trials are needed.
These findings suggest that neoadjuvant chemoimmunotherapy regimens were associated with higher pathologic and radiographic response rates compared with immunotherapy alone in locoregionally advanced HNSCC. These results call for phase 3 trials comparing these neoadjuvant regimens head to head.
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Baratz et al. (2026) studied this question.
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