TERT Promoter Methylation in Glioblastoma and its Paradoxical Association with Upregulated Gene Expression

Key Points

• To assess the relationship between TERT promoter methylation and gene expression in glioblastoma.
• Evaluated TERT promoter methylation status in glioblastoma within an Indian cohort.
• Analyzed the association between methylation and gene expression levels.
• Considered implications for therapeutic targets involving demethylating agents.
• TERT promoter methylation is significantly associated with increased gene expression in glioblastoma.
• Findings support the notion that TERT hyper-methylation is involved in the pathobiology of GBM.
• Study proposes potential therapeutic targeting of epigenetic alterations in GBM.