Analysis highlights the role of tert promoter methylation as a therapeutic target with implications for gene expression.
The present study is the first to assess the TERT promoter methylation status in GBM in an Indian cohort. TERT hyper-methylation is crucially implicated in the pathobiology of GBM by enhancing the gene expression. This epigenetic alteration may be an important therapeutic target, especially with the use of a specific demethylating agent.
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Purkait et al. (2026) studied this question.
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