What question did this study set out to answer?

To evaluate the effectiveness of prazosin and other alpha-1 adrenergic antagonists in treating nightmares and sleep issues in PTSD.

March 14, 2026Journal of Clinical Psychopharmacology1 citations

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Effects of Prazosin and Other Alpha-1 Adrenergic Antagonist Drugs on Nightmares and Sleep Disturbances in Posttraumatic Stress Disorder

OPOlga PonomarevaHarvard University SSSean R. StetsonBoston University BMBruce MeltzerBoston University

Key Points

To evaluate the effectiveness of prazosin and other alpha-1 adrenergic antagonists in treating nightmares and sleep issues in PTSD.
Literature review of existing efficacy for prazosin in PTSD-related nightmares.
Assessment of alternative alpha-1 blockers for cases where prazosin is not feasible.
Prazosin shows a strong evidence base for reducing nightmares in PTSD.
Alternative alpha-1 blockers may benefit some patients unable to tolerate prazosin.

Abstract

When available and clinically tolerated, prazosin continues to have the best evidence base for use in PTSD-related nightmares. When prazosin use is not feasible, alternative alpha-1 blockers may be effective in a subset of patients.

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Cite This Study

Ponomareva et al. (Thu,) studied this question.

synapsesocial.com/papers/69b4ba1818185d8a39802b11 https://doi.org/https://doi.org/10.1097/jcp.0000000000002164

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