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March 14, 2026Clinical Drug InvestigationOpen Access

Determinants and Prognostic Impact of In-Hospital Sodium-Glucose Cotransporter-2 Inhibitor Initiation in Patients with Heart Failure

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Authors

TOTakuya OkamotoKindai University Sakai HospitalKMKoichiro MatsumuraKindai University Sakai HospitalSHShohei HakozakiKindai University Sakai Hospital

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Overview

Retrospective analysis reveals cognitive dysfunction and malnutrition impact SGLT2i initiation and long-term outcomes in heart failure.

Key Points

  • This study evaluates the initiation rate of SGLT2 inhibitors in hospitalized heart failure patients and its prognostic impact.
  • Retrospective observational analysis of a prospective registry
  • Included 781 patients hospitalised for heart failure
  • Assessment of clinical factors associated with SGLT2i non-initiation using multivariable logistic regression
  • Evaluation of long-term outcomes through Cox proportional hazards analysis
  • SGLT2i initiation rate during hospitalization was 37.3%
  • Treatment discontinuation post-initiation occurred in 8.6%
  • Higher incidence of composite endpoint at 1 year in non-initiation group (37.5% vs 21.3%)
  • Cognitive dysfunction and malnutrition were linked to non-initiation
  • Not prescribed SGLT2i at discharge correlated with worse long-term outcomes (hazard ratio 1.70)

Cite This Study

Okamoto et al. (2026) studied this question.

synapsesocial.com/papers/69b4ba1818185d8a39802b76https://doi.org/10.1007/s40261-026-01539-x
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