What question did this study set out to answer?

This research aims to develop an efficient modeling framework for fluid-structure interaction in biological tissues.

March 14, 2026Annals of Biomedical Engineering0 citationsOpen Access

Efficient Multi-Fidelity Fluid–Structure Interaction Modeling for Pulsatile Blood Flow in Deformable Biological Tissues

CLChang Min LeeKorea Advanced Institute of Science and Technology YCYoungjae ChoiKorea Advanced Institute of Science and Technology KLKiwon LeeKorea Testing Certification

Key Points

This research aims to develop an efficient modeling framework for fluid-structure interaction in biological tissues.
Developed a multi-fidelity framework for fluid-structure interaction (FSI) in biological tissues.
Applied the framework to simulate pulsatile blood flow and tissue deformation.
Conducted large-scale parametric and optimization studies.
Demonstrated efficient simulation of hemodynamic responses under external pressure.
Highlighted potential applications in enhancing therapeutic device design and biomedical modeling.

Abstract

This multi-fidelity FSI framework enables efficient and accurate simulation of tissue deformation and hemodynamic responses under external pressure, providing a tractable platform for large-scale parametric and optimization studies. Its application to IPC highlights potential to enhance therapeutic device design and support broader applications in biomedical modeling and medical device development.

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