The Role of Artemisinin and its Derivatives in Cancer Therapy via Ferroptosis:A Systematic Review of In Vitro, In Vivo, and In Silico Studies

Q: What type of study is this?

This is a In Vitro Study study (also classified as: Systematic Review).

Suheda Rumeysa Osmanlioglu Dag; Iffet Irem Tatli Cankaya; Ayşe Mine Gençler Özkan

doi:10.2174/0118715206444970251227043020

March 9, 2026Anti-Cancer Agents in Medicinal Chemistry

The Role of Artemisinin and its Derivatives in Cancer Therapy via Ferroptosis:A Systematic Review of In Vitro, In Vivo, and In Silico Studies

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Key Points

This systematic review evaluates the role of artemisinin and its derivatives in cancer therapy, focusing on ferroptosis as a key mechanism.
Literature search conducted up to 2025 in databases such as PubMed, Web of Science, and Scopus.
In vitro, in vivo, and in silico studies included to assess the anticancer effects and mechanisms of action.
Analysis of interactions between artemisinin derivatives and ferroptosis-related proteins like GPX4 and transferrin receptor 1.
Dihydroartemisinin and artesunate promote reactive oxygen species accumulation and lipid peroxidation.
Experimental studies show tumor growth suppression with minimal systemic toxicity in animal models.
In silico findings reveal significant interactions with ferroptosis-related proteins, highlighting the mechanism of action.

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Implication

Systematic review reveals artemisinin compounds induce ferroptosis and reduce tumor growth in various cancers, indicating potential therapeutic benefits.

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Dag et al. (2026) studied this question.

synapsesocial.com/papers/69b4ba3618185d8a398030bf https://doi.org/10.2174/0118715206444970251227043020

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The Role of Artemisinin and its Derivatives in Cancer Therapy via Ferroptosis:A Systematic Review of In Vitro, In Vivo, and In Silico Studies

Key Points

No abstract yet

Implication

Discussion

Cite This Study

The Role of Artemisinin and its Derivatives in Cancer Therapy via Ferroptosis:A Systematic Review of In Vitro, In Vivo, and In Silico Studies

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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