Abstract: The aging of skin is a multifaceted process influenced by internal factors and external influences. These factors contribute to the breakdown of skin structure, diminished skin resilience, and observable indications of aging. Conventional topical formulations often fail to deliver active chemicals adequately due to the skin’s inherent barriers and the solubility and instability of numerous substances. Emerging nanotechnology-based technologies offer a viable solution to these restrictions. This paper analyzes the role of diverse organic and inorganic nanoparticle-based formulations as delivery systems in improving the distribution and efficacy of anti-aging agents. As part of its novelty, this article integrates findings on both synthetic and natural anti-aging compounds, providing a comprehensive comparison of their nano-enabled enhancements findings from in vitro and in vivo models, along with clinical studies. Comparative studies consistently demonstrate that nano-formulations surpass conventional approaches in enhancing antioxidant defense, stimulating collagen synthesis, and suppressing enzymes associated with skin aging. Keywords: topical system delivery, antioxidant, nanoparticles, anti-aging activity
Aloenida et al. (2026) studied this question.