What question did this study set out to answer?

To assess the predictive value of adiponectin and Lp-PLA2 on prognosis in cerebral infarction patients receiving rt-PA.

March 14, 2026BMC NeurologyOpen Access

Clinical value of APN combined with Lp-PLA2 in predicting functional outcome in patients with cerebral infarction underwent rt-PA intravenous thrombolysis

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Authors

SHSaifang Huang HCHe ChenWenzhou Hospital of Traditional Chinese Medicine XXXinli XiongShanghai East Hospital

Discussion

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Implication

This analysis reveals that adiponectin and Lp-PLA2 predict functional outcomes in patients with cerebral infarction undergoing rt-PA thrombolysis, indicating their potential clinical relevance.

Key Points

To assess the predictive value of adiponectin and Lp-PLA2 on prognosis in cerebral infarction patients receiving rt-PA.
Examined serum levels of adiponectin and Lp-PLA2 using enzyme-linked immunosorbent assay (ELISA).
Conducted multivariate logistic regression analysis to identify influencing factors.
Utilized the modified Rankin Scale (mRS) for classifying functional outcomes after 3 months.
Performed receiver operating characteristic (ROC) analysis for predictive value assessment.
Patients with cerebral infarction had significantly lower adiponectin and higher Lp-PLA2 levels compared to controls.
Adiponectin levels negatively correlated with mRS scores, while Lp-PLA2 levels positively correlated.
APN and Lp-PLA2 combined showed an area under the curve of 0.913 for functional outcome prediction.
Higher age and Lp-PLA2 levels were associated with poorer outcomes, while lower adiponectin levels indicated better outcomes.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/69b4fa9ab39f7826a300b4f7 https://doi.org/10.1186/s12883-026-04807-7

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Implication

This analysis reveals that adiponectin and Lp-PLA2 predict functional outcomes in patients with cerebral infarction undergoing rt-PA thrombolysis, indicating their potential clinical relevance.

Clinical value of APN combined with Lp-PLA2 in predicting functional outcome in patients with cerebral infarction underwent rt-PA intravenous thrombolysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Clinical value of APN combined with Lp-PLA2 in predicting functional outcome in patients with cerebral infarction underwent rt-PA intravenous thrombolysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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