Association between IL and 17A (rs2275913), IL-4 (rs2070874), NLRP3 (rs10754558) polymorphisms and COVID-19 in a cohort of professionals who worked in the first pandemic wave

Marcelo Cleyton da Silva Vieira; Beatriz dos Reis Marcelino; Marcos Jessé Abrahão Silva; Daniele Melo Sardinha; Sebastião Kauã de Sousa Bispo; Luana Nepomuceno Gondim Costa Lima; Karla Valéria Batista Lima

doi:10.1016/j.humimm.2026.111712

March 10, 2026Human ImmunologyOpen Access

Association between IL and 17A (rs2275913), IL-4 (rs2070874), NLRP3 (rs10754558) polymorphisms and COVID-19 in a cohort of professionals who worked in the first pandemic wave

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Key Points

This research examines the relationship between specific genetic polymorphisms and the severity of COVID-19. It aims to understand how these genetic factors may affect pulmonary involvement during the disease.
Analyzed genetic polymorphisms in IL-17A, IL-4, and NLRP3.
Evaluated associations with COVID-19 severity in a cohort of healthcare professionals.
Conducted multivariate analysis to assess significance of findings.
Identified potential association of IL-17A with pulmonary involvement in COVID-19.
Absence of independent significance in multivariate analysis suggests cautious interpretation of results.
Sample size limitations call for larger studies to confirm findings.

Implication

Exploratory analysis reveals potential links between genetic polymorphisms and COVID-19 severity in professionals, suggesting new research avenues.

Abstract

The rs2275913 polymorphism in IL-17A may contribute to pulmonary involvement in COVID-19; however, the absence of independent significance in multivariate analysis and sample size limitations indicate that these findings should be considered exploratory. Larger, well-powered studies are required to clarify the role of host genetic variation in COVID-19 severity.

Discussion

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Cite This Study

Vieira et al. (2026) studied this question.

synapsesocial.com/papers/69b4fa9ab39f7826a300b597 https://doi.org/10.1016/j.humimm.2026.111712

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Association between IL and 17A (rs2275913), IL-4 (rs2070874), NLRP3 (rs10754558) polymorphisms and COVID-19 in a cohort of professionals who worked in the first pandemic wave

Key Points

Implication

Abstract

Discussion

Cite This Study

Association between IL and 17A (rs2275913), IL-4 (rs2070874), NLRP3 (rs10754558) polymorphisms and COVID-19 in a cohort of professionals who worked in the first pandemic wave

Key Points

Implication

Abstract

Discussion

Cite This Study

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