Association of proteins involved in fetal lung development with respiratory outcomes in infancy

Q: What does this research mean for the field?

Low VEGF-A levels in cord blood protein profiles are associated with reduced lung function (tPTEF/tE) in healthy infants. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Noëmi Künstle; Olga Gorlanova; Carla Rebeca Da Silva Sena; Florian Wyler; Andrea Marten; Loretta Müller; Céline Rüttimann; Malena Gwerder; Ruth Steinberg; Pawan Sharma; Martin Röösli; Pablo Sinues; Benjamin Stoecklin; Jakob Usemann; Primo Schär; David Schürmann; Sven Schulzke; Philipp Latzin; Urs Frey; Fiona J. Beck; Xenia Bovermann; Carmen Casaulta; Marion Curdy; Carla Rebeca Da Silva Sena; Kees de Hoogh; Bettina Frauchiger; Urs Frey; Olga Gorlanova; Malena Gwerder; Léa Kim-Mi Ho Dac; Elisabeth Kieninger; Insa Korten; Noëmi Künstle; Philipp Latzin; Andrea Marten; Loretta Müller; Uri Nahum; Marc‐Alexander Oestreich; Martin Röösli; Céline Rüttimann; Sven Schulzke; Pablo Sinues; Ruth Steinberg; Benjamin Stoecklin; Carmen Streibel; Jakob Usemann; Florian Wyler; Sophie Yammine

doi:10.1016/j.rmed.2026.108773

March 1, 2026Respiratory MedicineOpen Access

Association of proteins involved in fetal lung development with respiratory outcomes in infancy

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Key Points

The research aims to evaluate associations between proteins involved in fetal lung development and respiratory outcomes in infants.
Hierarchical clustering of nine cord blood proteins in 369 infants
Use of linear and negative binomial regression analyses to examine associations
Focus on lung function at 4-6 weeks and respiratory symptoms during the first year
Identified four distinct protein profiles with varied growth factor and autophagy marker levels
Low VEGF-A levels were linked to reduced peak tidal expiratory flow (tPTEF/tE)
No significant association found between protein profiles and respiratory symptoms

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Implication

Hierarchical clustering analyzes protein profiles linked to lung function in infants, suggesting implications for risk factors.

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Cite This Study

Künstle et al. (2026) studied this question.

synapsesocial.com/papers/69b4fac6b39f7826a300b63b https://doi.org/10.1016/j.rmed.2026.108773

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Association of proteins involved in fetal lung development with respiratory outcomes in infancy

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Association of proteins involved in fetal lung development with respiratory outcomes in infancy

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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