Gut-initiated alpha synuclein fibrils drive parkinsonism phenotypes: temporal mapping of REM sleep behavior disorder-like and other non-motor symptoms

Daniel Dautan; Wojciech Paslawski; Sergio Montejo; D Doyon; Valentina I. Brioschi; Roberta Marongiu; Michael G. Kaplitt; Rong Chen; Valina L. Dawson; Xiaoqun Zhang; Ted M. Dawson; Per Svenningsson

doi:10.1186/s40035-026-00536-6

March 10, 2026Translational NeurodegenerationOpen Access

Gut-initiated alpha synuclein fibrils drive parkinsonism phenotypes: temporal mapping of REM sleep behavior disorder-like and other non-motor symptoms

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Key Points

To characterize the relationship between gut-initiated alpha synuclein and the development of non-motor symptoms in parkinsonism.
Experimental modeling of parkinsonism using gut-derived alpha synuclein fibrils
Assessment of REM sleep behavior disorder-like symptoms
Temporal mapping of disease progression and non-motor disturbances
Demonstrated progressive development of parkinsonism phenotypes
Highlighted the significant role of gut-brain signaling in symptom onset
Established a connection between alpha synuclein pathology and non-motor symptoms like RBD

Implication

Experimental characterization reveals the role of gut-initiated alpha synuclein in non-motor symptoms of parkinsonism, indicating complex interactions in disease progression.

Abstract

This work provides a detailed characterization of the progressive and multisystem nature of experimental parkinsonism, highlighting the interplay between αSyn pathology, gut-brain signaling, and the onset of non-motor disturbances, with a particular focus on RBD-like alterations in sleep.

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Cite This Study

Dautan et al. (2026) studied this question.

synapsesocial.com/papers/69b4fac6b39f7826a300b718 https://doi.org/10.1186/s40035-026-00536-6

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Gut-initiated alpha synuclein fibrils drive parkinsonism phenotypes: temporal mapping of REM sleep behavior disorder-like and other non-motor symptoms

Key Points

Implication

Abstract

Discussion

Cite This Study

Gut-initiated alpha synuclein fibrils drive parkinsonism phenotypes: temporal mapping of REM sleep behavior disorder-like and other non-motor symptoms

Key Points

Implication

Abstract

Discussion

Cite This Study

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