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March 14, 2026Gynecologic OncologyOpen Access

Lymphatic mapping and sentinel node biopsy in invasive Vulvar Paget's disease: A retrospective study and systematic review of the literature

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Authors

AFAlex FedericoAgostino Gemelli University PolyclinicGPGiusi PisanoLeiden University Medical CenterSFSimona Maria FragomeniAgostino Gemelli University Polyclinic

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Implication

Retrospective analysis finds sentinel node biopsy effective for staging in invasive vulvar Paget's disease, suggesting broader use in vulvar neoplasms.

Key Points

  • To evaluate the acceptability of sentinel node biopsy (SNB) for staging invasive vulvar Paget's disease (iVPD) and its implications for clinical practice.
  • Conducted a retrospective study on invasive vulvar Paget's disease patients.
  • Performed a systematic review of existing literature on sentinel node biopsy techniques.
  • Analyzed outcomes related to nodal staging and surgical methods.
  • Found that SNB is a potentially valid approach for nodal staging in iVPD.
  • Identified a significant rate of metastatic sentinel nodes in microinvasive VPD cases.
  • Recommended inguino-femoral surgical staging in microinvasive VPD due to metastatic risks.

Cite This Study

Federico et al. (2026) studied this question.

synapsesocial.com/papers/69b4fb1bb39f7826a300ba46https://doi.org/10.1016/j.ygyno.2026.02.017
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