This analysis shows the influence of ETI availability on lung transplant needs in cystic fibrosis patients, indicating ongoing transplant indications.
ETI has reduced, but not eliminated, the need for a first-time lung transplant in pwCF. Indications for a first-time lung transplant persist in a small subset of pwCF who respond to ETI and in those with nonresponsive CFTR genotypes. Re-transplant remains an option for selected transplant recipients with chronic lung allograft dysfunction.
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Dhôte et al. (2026) studied this question.
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