Five-Year Competing Risk Analysis of Infectious and Non-Infectious Complications After Lung Transplantation: Real-World Evidence from a Multicenter EHR-Based Cohort

March 1, 2026JHLT OpenOpen Access

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Key Points

The research aims to assess the 5-year incidence of complications in lung transplant recipients using a competing risks analysis.
Analyzed data from 10,648 lung transplant recipients
Utilized the TriNetX U.S. Collaborative Network
Employed the Aalen-Johansen method for cumulative incidence estimation
Identified major infectious and non-infectious complications
Conducted statistical analyses to determine outcome significance
Infectious complications had a 5-year cumulative incidence of 30.88%
Non-infectious complications had a 5-year cumulative incidence of 30.28%
Mortality rate was recorded at 10.62%
Cytomegalovirus (CMV) presented the highest infectious burden at 17.02%
Statistical analyses revealed significant differences across the identified outcomes (p < 0.001)

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Analysis evaluates post-transplant outcomes in lung transplant recipients, highlighting infection and complication risks.

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Contreras et al. (2026) studied this question.

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