To examine how language deficits relate to different stages of tau accumulation in Alzheimer's disease.
Utilized PET imaging to assess tau accumulation stages in subjects with Alzheimer's disease.
Examined language measures to determine their relationship with Braak stages of pathology.
Conducted cognitive assessments to align with biological definitions of Alzheimer's.
Language deficits correlate with increased tau accumulation as identified through PET imaging.
Certain language measures provide insight into early cognitive impairment stages.
Findings support the potential for language assessments in diagnosing Alzheimer's disease.
Abstract
Language measures support early detection and staging of AD pathophysiology and contribute to better align cognitive assessment with biological definitions of the disease.