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March 14, 2026SHILAP Revista de lepidopterología0 citationsOpen Access

Association of Family History and Polygenic Risk Scores With Prostate Cancer in Africa

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IOIyanuoluwa OdoleCACaroline AndrewsIAIlir Agalliu

Key Points

  • This research examines how family history and polygenic risk scores relate to prostate cancer in African men.
  • Observed the relationship between family history and prostate cancer incidence
  • Assessed the impact of polygenic risk scores on prostate cancer independently of family history
  • Analyzed the reliability of reporting family history in the African context
  • Family history is a strong indicator of prostate cancer risk in African men
  • Polygenic risk scores also show a significant association with prostate cancer risk
  • Potential bias in reporting family history is acknowledged but unlikely to affect the findings

Abstract

FHx is a strong predictor of CaP in African men. PRS is also associated with CaP largely independently of FHx. FHx may not always be reliably reported in Africa but the magnitude of recall or reporting bias is unlikely to have negated the observed association.

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Cite This Study

Odole et al. (2026) studied this question.

synapsesocial.com/papers/69b4fbb1b39f7826a300bfe1https://doi.org/10.1200/go-25-00431
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