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March 14, 2026Poultry ScienceOpen Access

PKA and PKC signaling pathways mediate vitamin D₃-regulated intestinal phosphorus absorption in broiler chickens

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Authors

MLMengyuan LiuLXLi XiYZYu Zhou

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Overview

Experiments show PKA and PKC pathways influence phosphorus absorption in chickens, indicating possible regulatory mechanisms.

Key Points

  • To investigate how PKA and PKC signaling pathways mediate vitamin D₃-regulated phosphorus absorption in broiler chickens.
  • Conducted three experiments on dietary VD₃ levels and PKA/PKC inhibitors.
  • Measured growth performance and intestinal phosphorus transporter expression using mRNA and protein analysis.
  • After intraperitoneal injection of inhibitors, studied effects on NaPi-IIb expression and related protein ratios.
  • High dietary VD₃ levels improved phosphorus transporter expression in jejunum.
  • PKA inhibitor H-89 reduced NaPi-IIb expression but altered protein ratios of PI3K and ERK.
  • PKC inhibitor staurosporine also reduced NaPi-IIb expression and affected other protein ratios.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69b4fbf9b39f7826a300c837https://doi.org/10.1016/j.psj.2026.106762
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