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March 14, 2026OpenNanoOpen Access

Box-Behnken design-based development and optimization of potentiated antibacterial nanoemulgel for azithromycin

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Authors

IJIman S. JafaarOAOmar Mohammed AlwanAAAthmar Dhahir Habeeb Al-Shohani

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Overview

Optimization develops an antibacterial nanoemulgel for azithromycin, suggesting improved acne treatment.

Key Points

  • The goal is to develop a nanoemulgel for azithromycin to enhance its solubility and antibacterial efficacy against acne.
  • Developed an AZ-loaded nanoemulsion using tea tree oil and optimized it via Box-Behnken design.
  • Incorporated optimized nanoemulsion into a hyaluronic acid gel base.
  • Evaluated formulations for in vitro release, skin irritation, and antibacterial efficacy.
  • The optimized AZ nanoemulsion had a particle size of 58.72 nm and PDI of 0.262.
  • The 1.5% HA formulation showed a viscosity of 1671 cp and achieved 98% drug release in 6 hours.
  • In vivo studies demonstrated no skin irritation, with AZ-nanoemulgel showing a zone of inhibition of 51 mm against P. acnes.

Cite This Study

Jafaar et al. (2026) studied this question.

synapsesocial.com/papers/69b4fbf9b39f7826a300c862https://doi.org/10.1016/j.onano.2026.100298
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