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This study aims to understand the sex-biased roles of Yap1 and CD276 in immune suppression in medulloblastoma.

March 14, 2026Neuro-Oncology PediatricsOpen Access

MDB-33. sex Biased Roles of Yap1 and Cd276/B7-H3 in Medulloblastoma Immune Suppression

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Findings show sex-biased immune suppression in medulloblastoma, indicating key roles for Yap1 and CD276 in survival outcomes.

This study aims to understand the sex-biased roles of Yap1 and CD276 in immune suppression in medulloblastoma.
Utilized a mouse model of SHH medulloblastoma by genetically deleting Yap1
Conducted integrated multi-omics analysis
Assessed immune checkpoint regulation of Cd276/B7-H3
Performed cell culture experiments to evaluate T cell suppression
Analyzed human cancer gene signatures for prediction of survival outcomes
Yap1 deletion significantly prolongs survival in male but not female mice with MB
YAP1 regulates immune evasion significantly more in male MB cells
Blocking CD276 or deleting Yap1 reversed T cell suppression in vitro for males
Combined inhibition of YAP1 and CD276 is necessary to reverse T cell suppression in females
YAP1 target gene signatures predict survival in males but not in females across cancer types

Abdelfattah et al. (2025) studied this question.

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