Analysis of metabolic characteristics of epristeride in zebrafish based on LC-Q-TOF MS and its potential applications in doping control

Y. Wang; Zhongquan Li; Jiahui Cheng; Tingyuan Zheng; Peijie Chen; Xiaojun Deng; Pei-Chao Zhang; Bing Liu

doi:10.1039/d5ra09094f

January 1, 2026RSC AdvancesOpen Access

Analysis of metabolic characteristics of epristeride in zebrafish based on LC-Q-TOF MS and its potential applications in doping control

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Key Points

To analyze the metabolic characteristics of epristeride in zebrafish for potential applications in doping control.
Utilized LC-Q-TOF MS for metabolite identification
Studied metabolic profile in zebrafish models
Analyzed key metabolites relevant to sports medicine
Identified several key metabolites of epristeride
Demonstrated the compound's non-competitive inhibition of 5α-reductase
Highlighted potential implications in doping control practices

Implication

Analysis of epristeride demonstrates its metabolic profile in zebrafish, suggesting implications for anti-doping efforts.

Abstract

Epristeride, a novel non-competitive inhibitor of type II 5α-reductase, was studied for its metabolic profile in zebrafish using LC-HRMS, revealing key metabolites in sports medicine and anti-doping efforts.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69b4fbf9b39f7826a300c943 https://doi.org/10.1039/d5ra09094f

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Analysis of metabolic characteristics of epristeride in zebrafish based on LC-Q-TOF MS and its potential applications in doping control

Key Points

Implication

Abstract

Discussion

Cite This Study

Analysis of metabolic characteristics of epristeride in zebrafish based on LC-Q-TOF MS and its potential applications in doping control

Key Points

Implication

Abstract

Discussion

Cite This Study

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